concept

UNFOLDED PROTEIN RESPONSE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UNFOLDED PROTEIN RESPONSE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1210Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

UNFOLDED PROTEIN RESPONSE is a concept in neurodegeneration research. Key relationships include: co discussed, causes, activates. Associated with FRONTOTEMPORAL. Connected to 14 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	UNFOLDED PROTEIN RESPONSE
Key Genes/Proteins	ACHE, ACTIN, AD, AMPK, AMYLOID, APC
Related Diseases	AGING, ALS, ALZHEIMER'S DISEASE
Related Pathways	APOPTOSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Unfolded Protein Response (UPR)

mechanism · 3651 words

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Pathway Diagram

graph TD
    UNFOLDED_PROTEIN_RESPONSE["UNFOLDED PROTEIN RESPONSE"]
    UNFOLDED_PROTEIN_RESPONSE -->|"regulates"| ER_homeostasis["ER homeostasis"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Mtor["Mtor"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Apoptosis["Apoptosis"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Autophagy["Autophagy"]
    UNFOLDED_PROTEIN_RESPONSE -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    SPHK1["SPHK1"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    TARDBP["TARDBP"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    PINK1["PINK1"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    LC3["LC3"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    MTOR["MTOR"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    PTEN["PTEN"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    VCP["VCP"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE
    TBK1["TBK1"] -->|"activates"| UNFOLDED_PROTEIN_RESPONSE

Outgoing (147)

Target	Relation	Type	Str
microglia	active_in	cell_type	0.90
Protein Quality Control	activates	process	0.90
Protein Folding	modulates	process	0.90
macrophages	active_in	cell_type	0.90
hippocampus	active_in	brain_region	0.90
endothelial cells	active_in	cell_type	0.90
BAX/BCL-2 ratio	upstream_of	phenotype	0.90
cortex	active_in	brain_region	0.90
astrocytes	active_in	cell_type	0.90
neurons	active_in	cell_type	0.90
thalamus	active_in	brain_region	0.90
blood-brain barrier	active_in	brain_region	0.90
neural stem cells	active_in	cell_type	0.90
ER homeostasis	regulates	phenotype	0.90
Neuronal Apoptosis	mediates	process	0.90
oligodendrocytes	active_in	cell_type	0.90
Protein Folding	regulates	process	0.90
Apoptosis	associated_with	process	0.85
Protein Degradation	associated_with	process	0.85
Dipeptide Repeat Protein Aggregation	involved_in	process	0.85
BAX	upregulates	protein	0.85
Neurodegeneration	contributes_to	process	0.80
hypothalamus	active_in	brain_region	0.80
spinal cord	active_in	brain_region	0.80
ER homeostasis	associated_with	phenotype	0.80
pyramidal neurons	active_in	cell_type	0.80
aging	associated_with	phenotype	0.78
Cognition	associated_with	phenotype	0.75
Memory	associated_with	phenotype	0.75
Synaptic Function	associated_with	process	0.75
NK cells	active_in	cell_type	0.70
B cells	active_in	cell_type	0.70
dopaminergic neurons	active_in	cell_type	0.70
substantia nigra	active_in	brain_region	0.70
T cells	active_in	cell_type	0.70
prefrontal cortex	active_in	brain_region	0.70
pericytes	active_in	cell_type	0.70
ASTROCYTES	produces	cell_type	0.65
ASTROCYTES	phosphorylates	cell_type	0.65
ASTROCYTES	regulates	cell_type	0.65
APP	produces	gene	0.65
MITOCHONDRIAL DYSFUNCTION	interacts_with	phenotype	0.65
NEURONS	causes	cell_type	0.65
ER STRESS	regulates	phenotype	0.65
NEURODEGENERATION	protects_against	disease	0.65
AGING	regulates	phenotype	0.65
white matter	active_in	brain_region	0.60
VCP	markers	gene	0.60
GABAergic neurons	active_in	cell_type	0.60
cerebellum	active_in	brain_region	0.60

Incoming (1063)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
GENES	activates	gene	1.00
ER Stress	activates	process	0.95
Endoplasmic Reticulum Stress	associated_with	process	0.95
Endoplasmic Reticulum	activates	organelle	0.95
ALS	involves	disease	0.90
NF-kB signaling	crosstalk_with	pathway	0.90
STING	participates_in	gene	0.90
ALS	participates_in	gene	0.90
MTOR	participates_in	gene	0.90
ferroptosis	crosstalk_with	pathway	0.90
aging	involves	disease	0.90
TGF-beta signaling	crosstalk_with	pathway	0.90
frontotemporal dementia	involves	disease	0.90
spinal muscular atrophy	involves	disease	0.90
IFN	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
neurodegeneration	involves	disease	0.90
Parkinson's disease	involves	disease	0.90
BDNF	participates_in	gene	0.90
MAPK	participates_in	gene	0.90
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.90
PI3K	participates_in	gene	0.90
SLC7A11	participates_in	gene	0.90
GPX4	participates_in	gene	0.90
pyroptosis	crosstalk_with	pathway	0.90
GSK2606414	inhibits	drug	0.90
depression	involves	disease	0.90
glioblastoma	involves	disease	0.90
Alzheimer's disease	involves	disease	0.90
NLRP3	participates_in	gene	0.90
ROS	participates_in	gene	0.90
TNF	participates_in	gene	0.90
APOE	participates_in	gene	0.90
ER stress	activates	process	0.90
cGAS-STING	crosstalk_with	pathway	0.90
lipid metabolism	crosstalk_with	pathway	0.90
RNA	participates_in	gene	0.90
Als	therapeutic_target	disease	0.90
Als	activates	disease	0.90
Cancer	therapeutic_target	disease	0.90
Tdp-43 Fibrils	activates	protein	0.87
astrocytes	active_in	cell_type	0.85
neurons	active_in	cell_type	0.85
microglia	active_in	cell_type	0.85
IL-10	participates_in	gene	0.85
TGF	participates_in	gene	0.85
DAM microglia	active_in	cell_type	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

neurodegeneration | 2026-04-28 | 7 hypotheses Top: 0.662

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.793

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

closed · Rounds: 4 · Score: 0.76 · 2026-04-28

The study shows VCP-mutant astrocytes exhibit hypoxia response activation withou

closed · Rounds: 4 · Score: 0.78 · 2026-04-13

Related Research

Hypotheses and analyses mentioning UNFOLDED PROTEIN RESPONSE in their description or question text

No additional research found